Mitochondrial Oxidative Metabolism: An Emerging Therapeutic Target to Improve CKD Outcomes.

ABSTRACT: Chronic kidney disease (CKD) predisposes one toward end-stage renal disease (ESRD) and its associated morbidity and mortality. Significant metabolic perturbations in conjunction with alterations in redox status during CKD may induce increased production of reactive oxygen species (ROS), including superoxide (O₂^●-) and hydrogen peroxide (H₂O₂). Increased O₂^●- and H₂O₂ may contribute to the overall progression of renal injury as well as catalyze the onset of comorbidities. In this review, we discuss the role of mitochondrial oxidative metabolism in the pathology of CKD and the recent developments in treating CKD progression specifically targeted to the mitochondria. Recently published results from a Phase

SUBMITTER: Mapuskar KA 

PROVIDER: S-EPMC10295466 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature