Causal Associations between Functional/Structural Connectivity and Stroke: A Bidirectional Mendelian Randomization Study.

ABSTRACT: Disruption of brain resting-state networks (RSNs) is known to be related to stroke exposure, but determining causality can be difficult in epidemiological studies. We used data on genetic variants associated with the levels of functional (FC) and structural connectivity (SC) within 7 RSNs identified from a genome-wide association study (GWAS) meta-analysis among 24,336 European ancestries. The data for stroke and its subtypes were obtained from the MEGASTROKE consortium, including up to 520,000 participants. We conducted a two-sample bidirectional Mendelian randomization (MR) study to investigate the causality relationship between FC and SC within 7 RSNs and stroke and its subtypes. The results showed that lower global mean FC and limbic network FC were associated with a higher risk of any

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10295514 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature