Updates in Glioblastoma Immunotherapy: An Overview of the Current Clinical and Translational Scenario.

ABSTRACT: Glioblastoma (GBM) is the most common and aggressive central nervous system tumor, requiring multimodal management. Due to its malignant behavior and infiltrative growth pattern, GBM is one of the most difficult tumors to treat and gross total resection is still considered to be the first crucial step. The deep understanding of GBM microenvironment and the possibility of manipulating the patient's innate and adaptive immune system to fight the neoplasm represent the base of immunotherapeutic strategies that currently express the future for the fight against GBM. Despite the immunotherapeutic approach having been successfully adopted in several solid and haematologic neoplasms, immune resistance and the immunosuppressive environment make the use of these strategies challenging in GBM treatm

SUBMITTER: Bianconi A 

PROVIDER: S-EPMC10295612 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature