A SERS Composite Hydrogel Device for Point-of-Care Analysis of Neurotransmitter in Whole Blood.

ABSTRACT: Point-of-care analysis of neurotransmitters in body fluids plays a significant role in healthcare improvement. Conventional approaches are limited by time-consuming procedures and usually require laboratory instruments for sample preparation. Herein, we developed a surface enhanced Raman spectroscopy (SERS) composite hydrogel device for the rapid analysis of neurotransmitters in whole blood samples. The PEGDA/SA composite hydrogel enabled fast separation of small molecules from the complex blood matrix, while the plasmonic SERS substrate allowed for the sensitive detection of target molecules. 3D printing was employed to integrate the hydrogel membrane and the SERS substrate into a systematic device. The sensor achieved highly sensitive detection of dopamine in whole blood samples with a l

SUBMITTER: Wu L 

PROVIDER: S-EPMC10295853 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature