Melatonin: Facts, Extrapolations and Clinical Trials.

ABSTRACT: Melatonin is a fascinating molecule that has captured the imagination of many scientists since its discovery in 1958. In recent times, the focus has changed from investigating its natural role as a transducer of biological time for physiological systems to hypothesized roles in virtually all clinical conditions. This goes along with the appearance of extensive literature claiming the (generally) positive benefits of high doses of melatonin in animal models and various clinical situations that would not be receptor-mediated. Based on the assumption that melatonin is safe, high doses have been administered to patients, including the elderly and children, in clinical trials. In this review, we critically review the corresponding literature, including the hypotheses that melatonin acts as a sc

SUBMITTER: Boutin JA 

PROVIDER: S-EPMC10295901 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature