Genetic Insights into Obesity and Brain: Combine Mendelian Randomization Study and Gene Expression Analysis.

ABSTRACT: As a major public-health concern, obesity is imposing an increasing social burden around the world. The link between obesity and brain-health problems has been reported, but controversy remains. To investigate the relationship among obesity, brain-structure changes and diseases, a two-stage analysis was performed. At first, we used the Mendelian-randomization (MR) approach to identify the causal relationship between obesity and cerebral structure. Obesity-related data were retrieved from the Genetic Investigation of ANthropometric Traits (GIANT) consortium and the UK Biobank, whereas the cortical morphological data were from the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) consortium. Further, we extracted region-specific expressed genes according to the Allen Human Brian

SUBMITTER: Chen L 

PROVIDER: S-EPMC10295948 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature