Non-Canonical Amino Acids as Building Blocks for Peptidomimetics: Structure, Function, and Applications.

ABSTRACT: This review provides a fresh overview of non-canonical amino acids and their applications in the design of peptidomimetics. Non-canonical amino acids appear widely distributed in nature and are known to enhance the stability of specific secondary structures and/or biological function. Contrary to the ubiquitous DNA-encoded amino acids, the structure and function of these residues are not fully understood. Here, results from experimental and molecular modelling approaches are gathered to classify several classes of non-canonical amino acids according to their ability to induce specific secondary structures yielding different biological functions and improved stability. Regarding side-chain modifications, symmetrical and asymmetrical α,α-dialkyl glycines, Cα to Cα cyclized amino acids, proli

SUBMITTER: Castro TG 

PROVIDER: S-EPMC10296201 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature