Pannexin-1 Modulates Inhibitory Transmission and Hippocampal Synaptic Plasticity.

ABSTRACT: Pannexin-1 (Panx1) hemichannel is a non-selective transmembrane channel that may play important roles in intercellular signaling by allowing the permeation of ions and metabolites, such as ATP. Although recent evidence shows that the Panx1 hemichannel is involved in controlling excitatory synaptic transmission, the role of Panx1 in inhibitory transmission remains unknown. Here, we studied the contribution of Panx1 to the GABAergic synaptic efficacy onto CA1 pyramidal neurons (PyNs) by using patch-clamp recordings and pharmacological approaches in wild-type and Panx1 knock-out (Panx1-KO) mice. We reported that blockage of the Panx1 hemichannel with the mimetic peptide ¹⁰Panx1 increases the synaptic level of endocannabinoids (eCB) and the activation of cannabinoid receptors type 1

SUBMITTER: Garcia-Rojas F 

PROVIDER: S-EPMC10296222 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature