Metabolomics-Guided Identification of a Distinctive Hepatocellular Carcinoma Signature.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is a major contributor to cancer-related morbidity and mortality burdens globally. Given the fundamental metabolic activity of hepatocytes within the liver, hepatocarcinogenesis is bound to be characterized by alterations in metabolite profiles as a manifestation of metabolic reprogramming.

Methods

HCC and adjacent non-tumoral liver specimens were obtained from patients after HCC resection. Global patterns in tissue metabolites were identified using non-targeted ¹H Nuclear Magnetic Resonance (¹H-NMR) spectroscopy whereas specific metabolites were quantified using targeted liquid chromatography-mass spectrometry (LC/MS).

Results

Principal component analysis (PCA) within our ¹H-NMR dataset identi

SUBMITTER: Tambay V 

PROVIDER: S-EPMC10296227 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature