Serine/Threonine Protein Phosphatases 1 and 2A in Lung Endothelial Barrier Regulation.

ABSTRACT: Vascular barrier dysfunction is characterized by increased permeability and inflammation of endothelial cells (ECs), which are prominent features of acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and sepsis, and a major complication of the SARS-CoV-2 infection and COVID-19. Functional impairment of the EC barrier and accompanying inflammation arises due to microbial toxins and from white blood cells of the lung as part of a defensive action against pathogens, ischemia-reperfusion or blood product transfusions, and aspiration syndromes-based injury. A loss of barrier function results in the excessive movement of fluid and macromolecules from the vasculature into the interstitium and alveolae resulting in pulmonary edema and collapse of the architecture and function of

SUBMITTER: Patil RS 

PROVIDER: S-EPMC10296329 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature