Preoperative Prognostic Index for Patients with Brain Metastases-A Population-Based Multi-Centre Study.

ABSTRACT:

Background

Brain metastases (BM) are common in cancer patients and are associated with high morbidity and mortality. Surgery is an option, but the optimal selection of patients for surgery is challenging and controversial. Current prognostication tools are not ideal for preoperative prognostication. By using a reference population (derivation data set) and two external populations (validation data set) of patients who underwent surgery for BM, we aimed to create and validate a preoperative prognostic index.

Methods

The derivation data set consists of 590 patients who underwent surgery for BM (2011-2018) at Oslo University Hospital. We identified variables associated with survival and created a preoperative prognostic index with four prognostic groups, which was validated on

SUBMITTER: Winther RR 

PROVIDER: S-EPMC10296417 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature