Oncologic Outcomes of Lymph Node Dissection at Salvage Radical Prostatectomy.

ABSTRACT:

Background

Lymph node invasion (LNI) represents a poor prognostic factor after primary radical prostatectomy (RP) for prostate cancer (PCa). However, the impact of LNI on oncologic outcomes in salvage radical prostatectomy (SRP) patients is unknown.

Objective

To investigate the impact of lymph node dissection (LND) and pathological lymph node status (pNX vs. pN0 vs. pN1) on long-term oncologic outcomes of SRP patients.

Patients and methods

Patients who underwent SRP for recurrent PCa between 2000 and 2021 were identified from 12 high-volume centers. Kaplan-Meier analyses and multivariable Cox regression models were used. Endpoints were biochemical recurrence (BCR), overall survival (OS), and cancer-specific survival (CSS).

Results

Of 853 SRP patients, 87% (n

SUBMITTER: Preisser F 

PROVIDER: S-EPMC10296518 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature