Ontology highlight
ABSTRACT:
SUBMITTER: Eken E
PROVIDER: S-EPMC10296543 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Eken Eda E Estores David S DS Cicali Emily J EJ Wiisanen Kristin K KK Johnson Julie A JA
Pharmacogenomics and personalized medicine 20230623
Proton pump inhibitors (PPIs) are commonly used medications to treat acid-related conditions, including gastro-esophageal reflux disease (GERD). Gastroenterology guidelines mention the importance of CYP2C19 in PPI metabolism and the influence of <i>CYP2C19</i> genetic variations on variable responses to PPIs, but do not currently recommend the genotyping of <i>CYP2C19</i> prior to prescribing PPIs. There are strong data to support the influence of <i>CYP2C19</i> genetic variations on the pharmac ...[more]