Circulating Tumor DNA in the Management of Early-Stage Breast Cancer.

ABSTRACT: Liquid biopsies refer to the isolation and analysis of tumor-derived biological material from body fluids, most commonly blood, in order to provide clinically valuable information for the management of cancer patients. Their non-invasive nature allows to overcome the limitations of tissue biopsy and complement the latter in guiding therapeutic decision-making. In the past years, several studies have demonstrated that circulating tumor DNA (ctDNA) detection can be used in the clinical setting to improve patient prognosis and monitor therapy response, especially in metastatic cancers. With the advent of significant technological advances in assay development, ctDNA can now be accurately and reliably identified in early-stage cancers despite its low levels in the bloodstream. In this review,

SUBMITTER: Vlataki K 

PROVIDER: S-EPMC10296563 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature