Neuroanatomical Alterations in the CNTNAP2 Mouse Model of Autism Spectrum Disorder.

ABSTRACT: Autism spectrum disorder (ASD) is associated with neurodevelopmental alterations, including atypical forebrain cellular organization. Mutations in several ASD-related genes often result in cerebral cortical anomalies, such as the abnormal developmental migration of excitatory pyramidal cells and the malformation of inhibitory neuronal circuitry. Notably here, mutations in the CNTNAP2 gene result in ectopic superficial cortical neurons stalled in lower cortical layers and alterations to the balance of cortical excitation and inhibition. However, the broader circuit-level implications of these findings have not been previously investigated. Therefore, we assessed whether ectopic cortical neurons in CNTNAP2 mutant mice form aberrant connections with higher-order thalamic nuclei, potentially a

SUBMITTER: Gandhi T 

PROVIDER: S-EPMC10296611 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature