The Distinctive Features behind the Aggressiveness of Oral and Cutaneous Squamous Cell Carcinomas.

ABSTRACT: Squamous cell carcinomas arise from stratified squamous epithelia. Here, a comparative analysis based on recent studies defining the genetic alterations and composition of the stroma of oral and cutaneous squamous cell carcinomas (OSCC and CSCC, respectively) was performed. Both carcinomas share some but not all histological and genetic features. This review was focused on how mutations in tumor suppressor genes and protooncogenes cooperate to determine the differentiation, aggressiveness, and metastatic potential of OSCC and CSCC. In fact, driver mutations in tumor suppressor genes are more frequently observed in OSCC than CSCC. These include mutations in TP53 (encoding pP53 protein), CDKN2A (encoding cyclin dependent kinase inhibitor 2A), FAT1 (encoding FAT atypical

SUBMITTER: Alonso-Juarranz M 

PROVIDER: S-EPMC10296732 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature