Clinical Features of COVID-19 Vaccine-Associated Autoimmune Hepatitis: A Systematic Review.

ABSTRACT: Autoimmune hepatitis (AIH) is an inflammatory liver disease wherein the body's immune system instigates an attack on the liver, causing inflammation and hepatic impairment. This disease usually manifests in genetically predisposed individuals and is triggered by stimuli or environments such as viral infections, environmental toxins, and drugs. The causal role of COVID-19 vaccination in AIH remains uncertain. This review of 39 cases of vaccine-related AIH indicates that female patients above the age of 50 years or those with potential AIH risk factors may be susceptible to vaccine-related AIH, and the clinical features of vaccine-associated AIH are similar to those of idiopathic AIH. These features commonly manifest in patients after the first dose of vaccination, with symptom onset typical

SUBMITTER: Zhou H 

PROVIDER: S-EPMC10297001 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature