Adenosine A_2A Receptor Activation Regulates Niemann-Pick C1 Expression and Localization in Macrophages.

ABSTRACT: Adenosine plays an important role in modulating immune cell function, particularly T cells and myeloid cells, such as macrophages and dendritic cells. Cell surface adenosine A_2A receptors (A_2AR) regulate the production of pro-inflammatory cytokines and chemokines, as well as the proliferation, differentiation, and migration of immune cells. In the present study, we expanded the A_2AR interactome and provided evidence for the interaction between the receptor and the Niemann-Pick type C intracellular cholesterol transporter 1 (NPC1) protein. The NPC1 protein was identified to interact with the C-terminal tail of A_2AR in RAW 264.7 and IPMФ cells by two independent and parallel proteomic approaches. The interaction between the NPC1 protein and the ful

SUBMITTER: Skopal A 

PROVIDER: S-EPMC10297445 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature