Genetic Characterization of Rat Hepatic Stellate Cell Line PAV-1.

ABSTRACT: The rat hepatic stellate cell line PAV-1 was established two decades ago and proposed as a cellular model to study aspects of hepatic retinoic acid metabolism. This cell line exhibits a myofibroblast-like phenotype but also has the ability to store retinyl esters and synthesize retinoic acid from its precursor retinol. Importantly, when cultured with palmitic acid alone or in combination with retinol, the cells switch to a deactivated phenotype in which the proliferation and expression of profibrogenic marker genes are suppressed. Despite these interesting characteristics, the cell line has somehow fallen into oblivion. However, based on the fact that working with in vivo models is becoming increasingly complicated, genetically characterized established cell lines that mimic aspects of hep

SUBMITTER: Gaberlein K 

PROVIDER: S-EPMC10297474 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature