Metabolic Silencing via Methionine-Based Amino Acid Restriction in Head and Neck Cancer.

ABSTRACT: In recent years, various forms of caloric restriction (CR) and amino acid or protein restriction (AAR or PR) have shown not only success in preventing age-associated diseases, such as type II diabetes and cardiovascular diseases, but also potential for cancer therapy. These strategies not only reprogram metabolism to low-energy metabolism (LEM), which is disadvantageous for neoplastic cells, but also significantly inhibit proliferation. Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumour types, with over 600,000 new cases diagnosed annually worldwide. With a 5-year survival rate of approximately 55%, the poor prognosis has not improved despite extensive research and new adjuvant therapies. Therefore, for the first time, we analysed the potential of methionine res

SUBMITTER: Wunsch AC 

PROVIDER: S-EPMC10297726 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature