In silico optimization of heparin microislands in microporous annealed particle hydrogel for endothelial cell migration.

ABSTRACT: Biomaterials capable of generating growth factor gradients have shown success in guiding tissue regeneration, as growth factor gradients are a physiologic driver of cell migration. Of particular importance, a focus on promoting endothelial cell migration is vital to angiogenesis and new tissue formation. Microporous Annealed Particle (MAP) scaffolds represent a unique niche in the field of regenerative biomaterials research as an injectable biomaterial with an open porosity that allows cells to freely migrate independent of material degradation. Recently, we have used the MAP platform to heterogeneously include spatially isolated heparin-modified microgels (heparin microislands) which can sequester growth factors and guide cell migration. In in vitro sprouting angiogenesis assays, we obser

SUBMITTER: Pruett LJ 

PROVIDER: S-EPMC10297728 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature