The Reversion of the Epigenetic Signature of Coronary Heart Disease in Response to Smoking Cessation.

ABSTRACT: Coronary heart disease (CHD) is the leading cause of death worldwide. However, current diagnostic tools for CHD, such as coronary computed tomography angiography (CCTA), are poorly suited for monitoring treatment response. Recently, we have introduced an artificial-intelligence-guided integrated genetic-epigenetic test for CHD whose core consists of six assays that determine methylation in pathways known to moderate the pathogenesis of CHD. However, whether methylation at these six loci is sufficiently dynamic to guide CHD treatment response is unknown. To test that hypothesis, we examined the relationship of changes in these six loci to changes in cg05575921, a generally accepted marker of smoking intensity, using DNA from a cohort of 39 subjects undergoing a 90-day smoking cessation inte

SUBMITTER: Philibert R 

PROVIDER: S-EPMC10297911 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature