The Role of Cocaine- and Amphetamine-Regulated Transcript (CART) in Cancer: A Systematic Review.

ABSTRACT: The functions of cocaine- and amphetamine-regulated transcript (CART) neuropeptide encoded by the CARTPT gene vary from modifying behavior and pain sensitivity to being an antioxidant. Putative CART peptide receptor GPR160 was implicated recently in the pathogenesis of cancer. However, the exact role of CART protein in the development of neoplasms remains unclear. This systematic review includes articles retrieved from the Scopus, PubMed, Web of Science and Medline Complete databases. Nineteen publications that met the inclusion criteria and describe the association of CART and cancer were analyzed. CART is expressed in various types of cancer, e.g., in breast cancer and neuroendocrine tumors (NETs). The role of CART as a potential biomarker in breast cancer, stomach adenocarcinoma,

SUBMITTER: Owe-Larsson M 

PROVIDER: S-EPMC10297965 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature