The Role of Fractalkine in the Regulation of Endometrial Iron Metabolism in Iron Deficiency.

ABSTRACT: Iron is a crucial element in the human body. Endometrial iron metabolism is implicated in endometrium receptivity and embryo implantation. Disturbances of the maternal as well as the endometrial iron homeostasis, such as iron deficiency, can contribute to the reduced development of the fetus and could cause an increased risk of adverse pregnancy outcomes. Fractalkine is a unique chemokine that plays a role in the communication between the mother and the fetus. It has been demonstrated that FKN is involved in the development of endometrial receptivity and embryo implantation, and it functions as a regulator of iron metabolism. In the present study, we examined the effect of FKN on the iron metabolism of HEC-1A endometrial cells in a state of iron deficiency mediated by desferrioxamine treat

SUBMITTER: Pandur E 

PROVIDER: S-EPMC10298019 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature