Bioengineered Bovine Papillomavirus L1 Protein Virus-like Particle (VLP) Vaccines for Enhanced Induction of CD8 T Cell Responses through Cross-Priming.

ABSTRACT: Safe and effective T cell vaccines are needed for the treatment or prevention of cancers as well as infectious agents where vaccines for neutralizing antibodies have performed poorly. Recent research highlights an important role for tissue-resident memory T cells (T_RM cells) in protective immunity and the role of a subset of dendritic cells that are capable of cross-priming for the induction of T_RM cells. However, efficient vaccine technologies that operate through cross-priming and induce robust CD8+ T cell responses are lacking. We developed a platform technology by genetically engineering the bovine papillomavirus L1 major capsid protein to insert a polyglutamic acid/cysteine motif in place of wild-type amino acids in the HI loop. Virus-like particles (VLPs) are fo

SUBMITTER: Viscidi RP 

PROVIDER: S-EPMC10298155 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature