IL-7 Deficiency Exacerbates Atopic Dermatitis in NC/Nga Mice.

ABSTRACT: Interleukin-7 (IL-7) plays a vital role in the homeostasis of CD4⁺ and CD8⁺ T cells. Although IL-7 has been implicated in T helper (Th)1- and Th17-mediated autoinflammatory diseases, its role in Th2-type allergic disorders, such as atopic dermatitis (AD), remains unclear. Thus, to elucidate the effects of IL-7 deficiency on AD development, we generated IL-7-deficient AD-prone mice by backcrossing IL-7 knockout (KO) B6 mice onto the NC/Nga (NC) mouse strain, a model for human AD. As expected, IL-7 KO NC mice displayed defective development of conventional CD4⁺ and CD8⁺ T cells compared with wild type (WT) NC mice. However, IL-7 KO NC mice presented with enhanced AD clinical scores, IgE hyperproduction, and increased epidermal thickness compared wi

SUBMITTER: Park HJ 

PROVIDER: S-EPMC10298193 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature