Quantitative Analysis of Isoform Switching in Cancer.

ABSTRACT: Over the past 8 years, multiple studies examined the phenomenon of isoform switching in human cancers and discovered that isoform switching is widespread, with hundreds to thousands of such events per cancer type. Although all of these studies used slightly different definitions of isoform switching, which in part led to a rather poor overlap of their results, they all leveraged transcript usage, a proportion of the transcript's expression in the total expression level of the parent gene, to detect isoform switching. However, how changes in transcript usage correlate with changes in transcript expression is not sufficiently explored. In this article, we adopt the most common definition of isoform switching and use a state-of-the-art tool for the analysis of differential transcript usage, S

SUBMITTER: Dolgalev G 

PROVIDER: S-EPMC10298363 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature