Genetic Influence on Treatment Response in Psoriasis: New Insights into Personalized Medicine.

ABSTRACT: Psoriasis is a chronic inflammatory disease with an established genetic background. The HLA-Cw*06 allele and different polymorphisms in genes involved in inflammatory responses and keratinocyte proliferation have been associated with the development of the disease. Despite the effectiveness and safety of psoriasis treatment, a significant percentage of patients still do not achieve adequate disease control. Pharmacogenetic and pharmacogenomic studies on how genetic variations affect drug efficacy and toxicity could provide important clues in this respect. This comprehensive review assessed the available evidence for the role that those different genetic variations may play in the response to psoriasis treatment. One hundred fourteen articles were included in this qualitative synthesis.

SUBMITTER: Berna-Rico E 

PROVIDER: S-EPMC10298473 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature