Attenuation of LPS-Induced Lung Injury by Benziodarone via Reactive Oxygen Species Reduction.

ABSTRACT: As overproduction of reactive oxygen species (ROS) causes various diseases, antioxidants that scavenge ROS, or inhibitors that suppress excessive ROS generation, can be used as therapeutic agents. From a library of approved drugs, we screened compounds that reduced superoxide anions produced by pyocyanin-stimulated leukemia cells and identified benzbromarone. Further investigation of several of its analogues showed that benziodarone possessed the highest activity in reducing superoxide anions without causing cytotoxicity. In contrast, in a cell-free assay, benziodarone induced only a minimal decrease in superoxide anion levels generated by xanthine oxidase. These results suggest that benziodarone is an inhibitor of NADPH oxidases in the plasma membrane but is not a superoxide anion scaveng

SUBMITTER: Ishihara T 

PROVIDER: S-EPMC10298550 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature