In Vitro Safety Assessment of In-House Synthesized Titanium Dioxide Nanoparticles: Impact of Washing and Temperature Conditions.

ABSTRACT: Titanium dioxide nanoparticles (TiO₂ NPs) have been widely used in food, cosmetics, and biomedical research. However, human safety following exposure to TiO₂ NPs remains to be fully understood. The aim of this study was to evaluate the in vitro safety and toxicity of TiO₂ NPs synthesized via the Stöber method under different washing and temperature conditions. TiO₂ NPs were characterized by their size, shape, surface charge, surface area, crystalline pattern, and band gap. Biological studies were conducted on phagocytic (RAW 264.7) and non-phagocytic (HEK-239) cells. Results showed that washing amorphous as-prepared TiO₂ NPs (T1) with ethanol while applying heat at 550 °C (T2) resulted in a reduction in the surface area and charge comp

SUBMITTER: Almomen A 

PROVIDER: S-EPMC10298741 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature