Derivation and external validation of a clinical prognostic model identifying children at risk of death following presentation for diarrheal care.

ABSTRACT: Diarrhea continues to be a leading cause of death for children under-five. Amongst children treated for acute diarrhea, mortality risk remains elevated during and after acute medical management. Identification of those at highest risk would enable better targeting of interventions, but available prognostic tools lack validation. We used clinical and demographic data from the Global Enteric Multicenter Study (GEMS) to build clinical prognostic models (CPMs) to predict death (in-treatment, after discharge, or either) in children aged ≤59 months presenting with moderate-to-severe diarrhea (MSD), in Africa and Asia. We screened variables using random forests, and assessed predictive performance with random forest regression and logistic regression using repeated cross-validation. We used data

SUBMITTER: Ahmed SM 

PROVIDER: S-EPMC10298785 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature