Stability Characterization of the Novel Anti-Cancer HM-10/10 HDL-Mimetic Peptide.

ABSTRACT: Epithelial adenocarcinoma of the ovary and colon are associated with the highest rates of cancer-related deaths in women in the U.S. The literature supports the role of HDL-associated apolipoproteins in the treatment of cancer and other pro-inflammatory diseases. Previously, we developed a novel 20-amino acid mimetic peptide, HM-10/10, which potently inhibits tumor development and growth in colon and ovarian cancer. Here, we report the properties of HM-10/10 relative to its stability in vitro. The results demonstrated that HM-10/10 had the highest half-life in human plasma compared to plasma from other species tested. HM-10/10 demonstrated stability in human plasma and simulated gastric environment, increasing its promise as an oral pharmaceutical. However, under conditions modeling the sm

SUBMITTER: Dempsey MP 

PROVIDER: S-EPMC10298982 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature