Galanin 2 Receptor: A Novel Target for a Subset of Pancreatic Ductal Adenocarcinoma.

ABSTRACT: Galanin is a 30 amino acid peptide that stimulates three subtype receptors (GAL_1-3R). M89b is a lanthionine-stabilized, C-terminally truncated galanin analog that specifically stimulates GAL₂R. We investigated the potential of M89b as a therapeutic for pancreatic ductal adenocarcinoma (PDAC) and assessed its safety. The anti-tumor activity of subcutaneously injected M89b on the growth of patient-derived xenografts of PDAC (PDAC-PDX) in mice was investigated. In addition, the safety of M89b was assessed in vitro using a multi-target panel to measure the off-target binding and modulation of enzyme activities. In a PDAC-PDX with a high GAL₂R expression, M89b completely inhibited the growth of the tumor (p < 0.001), while in two PDAC-PDXs with low

SUBMITTER: Namsolleck P 

PROVIDER: S-EPMC10299363 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature