Diagnostic Performance of Dynamic Whole-Body Patlak [¹⁸F]FDG-PET/CT in Patients with Indeterminate Lung Lesions and Lymph Nodes.

ABSTRACT:

Background

Static [¹⁸F]FDG-PET/CT is the imaging method of choice for the evaluation of indeterminate lung lesions and NSCLC staging; however, histological confirmation of PET-positive lesions is needed in most cases due to its limited specificity. Therefore, we aimed to evaluate the diagnostic performance of additional dynamic whole-body PET.

Methods

A total of 34 consecutive patients with indeterminate pulmonary lesions were enrolled in this prospective trial. All patients underwent static (60 min p.i.) and dynamic (0-60 min p.i.) whole-body [¹⁸F]FDG-PET/CT (300 MBq) using the multi-bed-multi-timepoint technique (Siemens mCT FlowMotion). Histology and follow-up served as ground truth. Kinetic modeling factors were calculated using a two-compartment li

SUBMITTER: Weissinger M 

PROVIDER: S-EPMC10299392 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature