Association of the rs3864283 Polymorphism Located in the HINT1 Gene with Cigarette Use and Personality Traits.

ABSTRACT: Nicotine is the major reinforcing component of tobacco and it is believed that the pharmacological effects of nicotine motivate the initiation and maintenance of a smoking habit. HINT1 appears to play a role in the modulation of the effects of drug abuse. Hence, the aim of this study was the analysis of the association between the rs3864283 polymorphism of the HINT1 gene and cigarette use; the analysis of personality traits assessed by the means of the NEO-FFI Inventory; the analysis of anxiety measured by the STAI questionnaire; and the analysis of the interactions between the rs3864283 and both personality traits and anxiety. The study group consisted of 522 volunteers. Of these, 371 were cigarette users and 151 were never-smokers. The genomic DNA was isolated from venous blood us

SUBMITTER: Suchanecka A 

PROVIDER: S-EPMC10299401 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature