Pathophysiologic Contributions of Visceral Adiposity to Left Ventricular Diastolic Dysfunction.

ABSTRACT:

Background

Visceral fat produces inflammatory cytokines and may play a major role in heart failure with preserved ejection fraction (HFpEF). However, little data exist regarding how qualitative and quantitative abnormalities of visceral fat would contribute to left ventricular diastolic dysfunction (LVDD).

Methods

We studied 77 participants who underwent open abdominal surgery for intra-abdominal tumors (LVDD, n = 44; controls without LVDD, n = 33). Visceral fat samples were obtained during the surgery, and mRNA levels of inflammatory cytokines were measured. Visceral and subcutaneous fat areas were measured using abdominal computed tomography.

Results

Patients with significant LVDD had greater LV remodeling and worse LVDD than controls. While body weight, body mass i

SUBMITTER: Nagata R 

PROVIDER: S-EPMC10299441 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature