Regionalized Protein Localization Domains in the Zebrafish Hair Cell Kinocilium.

ABSTRACT: Sensory hair cells are the receptors for auditory, vestibular, and lateral line sensory organs in vertebrates. These cells are distinguished by "hair"-like projections from their apical surface collectively known as the hair bundle. Along with the staircase arrangement of the actin-filled stereocilia, the hair bundle features a single, non-motile, true cilium called the kinocilium. The kinocilium plays an important role in bundle development and the mechanics of sensory detection. To understand more about kinocilial development and structure, we performed a transcriptomic analysis of zebrafish hair cells to identify cilia-associated genes that have yet to be characterized in hair cells. In this study, we focused on three such genes-ankef1a, odf3l2a, and saxo2-because h

SUBMITTER: Erickson T 

PROVIDER: S-EPMC10299642 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature