The Use of the Cryopreserved Aortic Homograft for Aortic Valve Replacement: Is It Still an Option?

ABSTRACT: The indications for cryopreserved allografts in aortic valve replacement are still debatable. We aim to identify factors influencing early and long-term durability of the aortic homograft and to define subgroups of patients with an improved long-term quality of life, survival, and freedom from structural valve degeneration (SVD). We evaluated our series of 210 patients who underwent allograft implantation with a retrospective cohort study design over a period of 20 years. Endpoints were overall mortality, cardiac mortality related to SVD, the incidence of SVD, reoperation, and a composite endpoint comprising major adverse cardiac and cerebrovascular events (MACCEs), which includes cardiac death both related and not related to SVD, subsequent aortic valve surgery, new or recurrent infection

SUBMITTER: Nappi F 

PROVIDER: S-EPMC10299650 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature