Association of CETP Gene Polymorphisms and Haplotypes with Cardiovascular Risk.

ABSTRACT: Cholesteryl ester transfer protein (CETP) is known to influence HDL-C levels, potentially altering the profile of HDL subfractions and consequently cardiovascular risk (CVR). This study aimed to investigate the effect of five single-nucleotide polymorphisms (SNPs; rs1532624, rs5882, rs708272, rs7499892, and rs9989419) and their haplotypes (H) in the CETP gene on 10-year CVR estimated by the Systematic Coronary Risk Evaluation (SCORE), the Framingham Risk Score for Coronary Heart Disease (FRS_CHD) and Cardiovascular Disease (FRS_CVD) algorithms. Adjusted linear and logistic regression analyses were used to investigate the association of SNPs and 10 haplotypes (H1-H10) on 368 samples from the Hungarian general and Roma populations. The T allele of rs7499892

SUBMITTER: Piko P 

PROVIDER: S-EPMC10299660 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature