Characterization of the LysP2110-HolP2110 Lysis System in Ralstonia solanacearum Phage P2110.

ABSTRACT: Ralstonia solanacearum, a pathogen causing widespread bacterial wilt disease in numerous crops, currently lacks an optimal control agent. Given the limitations of traditional chemical control methods, including the risk of engendering drug-resistant strains and environmental harm, there is a dire need for sustainable alternatives. One alternative is lysin proteins that selectively lyse bacteria without contributing to resistance development. This work explored the biocontrol potential of the LysP2110-HolP2110 system of Ralstonia solanacearum phage P2110. Bioinformatics analyses pinpointed this system as the primary phage-mediated host cell lysis mechanism. Our data suggest that LysP2110, a member of the Muraidase superfamily, requires HolP2110 for efficient bacterial l

SUBMITTER: Chen K 

PROVIDER: S-EPMC10299722 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature