Prognostic and predictive values of the grading system of lymph node status in patients with advanced-stage gastric cancer.

ABSTRACT:

Background

Lymph node metastasis is one of the most important prognostic factors of gastric cancer. However, the effect of germinal centers in lymph nodes on the prognosis of patients with gastric cancer has not been reported. This study aimed to investigate the contribution of germinal center generation to prognostic parameters and clinicopathological significance in gastric cancer.

Methods

We retrospectively reviewed gastric cancer patients who underwent surgery from October 2012 to June 2022. We analyzed 5484 lymph nodes (210 patients) and calculated the lymph node metastasis rate (LNMR) and the proportion of non-metastatic lymph nodes containing three or more germinal centers (NML-GCP).

Results

Using a grading system that incorporated LNMR and NML-GCP. The tumors

SUBMITTER: Zhang XM 

PROVIDER: S-EPMC10299729 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature