Gut microbiota and Sjogren's syndrome: a two-sample Mendelian randomization study.

ABSTRACT:

Background

The link between the gut microbiota (GM) and Sjögren's Syndrome (SS) is well-established and apparent. Whether GM is causally associated with SS is uncertain.

Methods

The MiBioGen consortium's biggest available genome-wide association study (GWAS) meta-analysis (n=13,266) was used as the basis for a two-sample Mendelian randomization study (TSMR). The causal relationship between GM and SS was investigated using the inverse variance weighted, MR-Egger, weighted median, weighted model, MR-PRESSO, and simple model methods. In order to measure the heterogeneity of instrumental variables (IVs), Cochran's Q statistics were utilized.

Results

The results showed that genus Fusicatenibacter (odds ratio (OR) = 1.418, 95% confidence interval (CI), 1.072-1.874, P = 0.01

SUBMITTER: Cao Y 

PROVIDER: S-EPMC10299808 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature