Intrathecal CD8⁺CD20⁺ T Cells in Primary Progressive Multiple Sclerosis.

ABSTRACT:

Background and objective

Despite accumulating evidence of intrathecal inflammation in patients with primary progressive multiple sclerosis (PPMS), immunomodulatory and suppressive treatment strategies have proven unsuccessful. With this study, we investigated the involvement of CD20⁺ T cells and the effect of dimethyl fumarate on CD20⁺ T cells in PPMS.

Methods

The main outcomes in this observational, case-control study were flow cytometry assessments of blood and CSF CD20⁺ T cells and ELISA measurements of myelin basic protein and neurofilament light chain in untreated patients with PPMS and patients treated for 48 weeks with dimethyl fumarate or placebo. MRI measures included new and enlarging T2-weighted lesions over 48 weeks and lesion, no

SUBMITTER: von Essen MR 

PROVIDER: S-EPMC10299852 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature