Electron transfer and ROS production in brain mitochondria of intertidal and subtidal triplefin fish (Tripterygiidae).

ABSTRACT: While oxygen is essential for oxidative phosphorylation, O₂ can form reactive species (ROS) when interacting with electrons of mitochondrial electron transport system. ROS is dependent on O₂ pressure (PO₂) and has traditionally been assessed in O₂ saturated media, PO₂ at which mitochondria do not typically function in vivo. Mitochondrial ROS can be significantly elevated by the respiratory complex II substrate succinate, which can accumulate within hypoxic tissues, and this is exacerbated further with reoxygenation. Intertidal species are repetitively exposed to extreme O₂ fluctuations, and have likely evolved strategies to avoid excess ROS production. We evaluated mitochondrial electron leakage and ROS production in permeab

SUBMITTER: Devaux JBL 

PROVIDER: S-EPMC10299943 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature