Comparative genomics of infective Saccharomyces cerevisiae strains reveals their food origin.

ABSTRACT: Fungal infections are less studied than viral or bacterial infections and often more difficult to treat. Saccharomyces cerevisiae is usually identified as an innocuous human-friendly yeast; however, this yeast can be responsible for infections mainly in immunosuppressed individuals. S. cerevisiae is a relevant organism widely used in the food industry. Therefore, the study of food yeasts as the source of clinical infection is becoming a pivotal question for food safety. In this study, we demonstrate that S. cerevisiae strains cause infections to spread mostly from food environments. Phylogenetic analysis, genome structure analysis, and phenotypic characterization showed that the key sources of the infective strains are food products, such as bread and probiotic supplements. We observed tha

SUBMITTER: Morard M 

PROVIDER: S-EPMC10300040 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature