Early indicators of bipolar risk in preschool offspring of parents with bipolar disorder.

ABSTRACT:

Background

Offspring of parents with bipolar disorder (BD-I/II) are at increased risk to develop the disorder. Previous work indicates that bipolar spectrum disorder (BPSD) is often preceded by mood/anxiety symptoms. In school-age offspring of parents with BD, we previously built a risk calculator to predict BPSD onset, which generates person-level risk scores. Here, we test whether preschool symptoms predict school-age BPSD risk.

Methods

We assessed 113 offspring of parents with BD 1-3 times during preschool years (2-5 years old) and then approximately every 2 years for a mean of 10.6 years. We used penalized (lasso) regression with linear mixed models to assess relationships between preschool mood, anxiety, and behavioral symptoms (parent-reported) and school-age predictor

SUBMITTER: Hafeman DM 

PROVIDER: S-EPMC10300228 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature