Individualized estimated years from onset of Alzheimer's disease- related decline for adults with Down syndrome.

ABSTRACT:

Introduction

Adults with Down syndrome (DS) are at increased risk for Alzheimer's disease (AD) and vary in their age of transition from AD preclinical to prodromal or more advanced clinical stages. An empirically based method is needed to determine individual "estimated years from symptom onset (EYO)," the same construct used in studies of autosomal dominant AD .

Methods

Archived data from a previous study of > 600 adults with DS were examined using survival analysis methods. Age-specific prevalence of prodromal AD or dementia, cumulative risk, and EYOs were determined.

Results

Individualized EYOs for adults with DS ranging in age from 30 to 70+ were determined, dependent upon chronological age and clinical status.

Discussion

EYOs can be a useful tool for studi

SUBMITTER: Silverman W 

PROVIDER: S-EPMC10300244 | biostudies-literature | 2023 Apr-Jun

REPOSITORIES: biostudies-literature