Plasma and cerebrospinal fluid nonenzymatic protein damage is sustained in Alzheimer's disease.

ABSTRACT:

Background

Oxidative stress is considered to play an important role in the pathogenesis of Alzheimer's disease (AD). It has been observed that oxidative damage to specific protein targets affecting particular functional networks is one of the mechanisms by which oxidative stress contributes to neuronal failure and consequently loss of cognition and AD progression. Studies are lacking in which oxidative damage is measured at both systemic and central fluid levels and in the same cohort of patients. We aimed to determine the levels of both plasma and cerebrospinal fluid (CSF) nonenzymatic protein damage in patients in the continuum of AD and to evaluate the relation of this damage with clinical progression from mild cognitive impairment (MCI) to AD.

Methods

Different markers o

SUBMITTER: Dakterzada F 

PROVIDER: S-EPMC10300255 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature