In Vitro Inhibition of Evaporation with Perfluorohexyloctane, an Eye Drop for Dry Eye Disease.

ABSTRACT:

Objective

Perfluorohexyloctane (PFHO) MIEBO^TM, formerly (NOV03) is a single component, water-free eye drop approved by the Food and Drug Administration in the United States for the treatment of dry eye disease. We evaluated the in vitro inhibitory effect of PFHO on the evaporation rate (R_evap) of saline.

Methods

Evaporation rates were measured gravimetrically at 25°C or 35°C. The evaporation rate (R_evap) of phosphate-buffered saline (PBS) was measured following the application of 11-200 µL PFHO or 100 µL artificial tears (Soothe XP [Bausch + Lomb, Bridgewater, New Jersey], Systane Balance [Alcon, Fort Worth, Texas], and Systane Ultra [Alcon]). The effect of PFHO on the R_evap of PBS was further evaluated following the addition of 50

SUBMITTER: Vittitow J 

PROVIDER: S-EPMC10300294 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature