Myocardial Injury Thresholds for 4 High-Sensitivity Troponin Assays in U.S. Adults.

ABSTRACT:

Background

Myocardial injury is currently defined as a cardiac troponin above the sex-specific 99th percentile of a healthy reference population (upper reference limit [URL]).

Objectives

The purpose of this study was to estimate high-sensitivity (hs) troponin URLs in a representative sample of the U.S. adult population; overall and by sex, race/ethnicity, and age group.

Methods

Among adults participating in the 1999-2004 National Health and Nutrition Examination Survey (NHANES), we measured hs-troponin T using 1 assay (Roche) and hs-troponin I using 3 assays (Abbott, Siemens, and Ortho). In a strictly defined healthy reference subgroup, we estimated 99th percentile URLs for each assay using the recommended nonparametric method.

Results

Of 12,545 participants, 2

SUBMITTER: McEvoy JW 

PROVIDER: S-EPMC10300307 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature